| Author/Editor | Leonardis, Lea; Ogulin, Mateja | |
| Title | Pomen zvišane plazemske koncentracije adrenalina in noradrenalina pri bolnikih v zgodnji fazi ishemičnega cerebrovaskularnega insulta | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1991 | |
| Volume | str. 51 | |
| Language | slo | |
| Abstract | In the study, 30 patients with ischemic cerebrovascular insult were investigated in the first 21 days after the onset of the symptoms. We started from a hypothesis that in a case of a brain damage the activity of plasma adrenaline and noradrenaline is increased due to the increased symphatic activity. Since we presumed that the plasma activity of noradrenaline, adrenaline and the neurological status are mutually related, we simultaneously observed all three variables. Because of the potential influence of the stress on the plasma activity of adrenaline, we measured the dynamic activity of cortisol. In order to properly evaluate the neurological status, we analyzed different neurological scales and among them chose the one that gives the most suitable evaluation of patients with the cerebrovascular insult in the acute phase. The results of the study show that the neurological status of patients improves with time. During the time of examination the average activity of noradrenaline in plasma was above the normal values, whereas the average activity of adrenaline remains within the limits of normal conditions. The average values of activity of cortisol were above the upper limit of normal values only the first, the second and the 21-st day in case of female patients and the second day in case of male patients. The study reveals that the correlation between the evaluation of neurological status and activity of noradrenaline is not statistically significant. On the other hand, there is a statistically significant correlation between the evaluation of neurological status and the activity of adrenaline and cortisol. However, we believe that the two phenomena are independent. We explain the higher activities of adrenaline and cortisol in the first days of the experiment with a reaction of the organism to the stress. | |
| Descriptors | CEREBROVASCULAR DISORDERS CEREBRAL ISCHEMIA EPINEPHRINE NOREPINEPHRINE HYDROCORTISONE NEUROLOGIC EXAMINATION |