Author/Editor		Milanič, Tanja; Weber, Urška
Title		Navidezno življenje ogrožajoč dogodek: usmerjena anamneza, funkcijske kardiorespiratorne preiskave in bikemični pokazatelji
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		1999
Volume		str. 31
Language		slo
Abstract		Introductions: Apparent life-threatening event (ALTE) is defined as an episode that is frightening to the observer and in some cases, the observer even fears that the infant has died. The event is basically characterized by a disturbance in cardiorespiratory patterns (CRP). According to several studies, ALTE infants are at increased risk of subsequent dying of sudden infant death syndrome (SIDS), particularly when no treatable cause for the ALTE is found. Disturbances in CRP have also been found in SIDS victims and are thought to be due to chronic, clinically silent hypoxia. The latter has been demonstrated by several studies in both SIDS victims and in ALTE infants. Despite of this it is so far impossible to determine which ALTEs are at increased risk to die of SIDS. Today the most widely used method for evaluation of CRP in infants with ALTE is cardiorespirogram (CRG). Currently in ALTE cases CRG recordings provide the basis for the estimation of degree of risk for SIDS. However, it was also proposed that such an evaluation could be made on the basis of some new methods, such as ALTE taxonomic profile or through the markers of chronic hypoxia, for example body fluids hypoxanthine level. Objective: The aim of the present study was to verify the following issues: 1.) First hypothesis: In infants with ALTE there is statistically significant degree of correspondence between severity of such event and specific abnormality of the CRG recording in etiologically unexplained cases, while in explained ALTEs no such correspondence can be found. 2.) Second hypothesis: In infants with ALTE there is statistically significant degree of correspondence between the level of urinary hypoxantine and specific abnormality of the CRG recording. 3.) How many of all ALTE cases can be classified as etiologically explained or unexplained, receptively, after the standard diagnostic procedure and what are the major causes of such events.(Abstract truncated at 2000 characters.)
Descriptors		SUDDEN INFANT DEATH ANOXIA HYPOXANTHINE CREATININE INFANT CAUSE OF DEATH MONITORING, PHYSIOLOGIC GASTROESOPHAGEAL REFLUX NERVOUS SYSTEM DISEASES RESPIRATORY TRACT INFECTIONS