Author/Editor		Zakotnik, Breda; Čižman, Milan
Title		Cepljenja otrok s presajenimi organi in kostnim mozgom
Translated title		Vaccinations of solid organ or bone marrow transplant pediatric recipients
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 39, št. Suppl 1
Publication year		2000
Volume		str. 145-52
Language		slo
Abstract		Individuals with organ and bone marrow transplantation have impaired immunity and are at increased risk for infections and can experience more severe and complicated course of infection. Most vaccines are less immunogenic in those with impaired immunity than in normal individuals. Live vaccines are generally contraindicated in this group. Vaccination against vaccine preventable diseases are recommended before or after transplantation when efficacious and safe immune response is expected. The immune response can be determined by the determination of antibodies and booster doses can be added. The authors briefly review certain immunisation regimes and the appropriateness of vaccination in pediatric patients before and after solid organ and bone marrow transplantation.
Summary		Osebe po presaditvi čvrstih organov in kostnega mozga so zaradi prizadete imunosti bolj ogrožene za okužbe kot zdrave osebe in okužbe lahko potekajo težje in z zapleti. Večina cepiv je pri transplantiranih osebah manj imunogena kot pri osebah z normalno imunostjo. Živa oslabljena cepiva so na splošno kontraindicirana. Cepljenje je priporočljivo pred transplantacijo ali po transplantaciji, ko že pričakujemo ugoden odziv na cepiva. Imunski odgovor lahko pogosto zasledujemo z določanjem titra protiteles in po potrebi dodamo poživitveni odmerek. Avtorja predstavljata nekatere sheme za cepljenje in razpravljata o primernosti cepljenja otrok pred presaditvami čvrstih organov ali kostnega mozga in po njih.
Descriptors		BONE MARROW TRANSPLANTATION ORGAN TRANSPLANTATION VACCINATION CHILD