Author/Editor		Beravs, Katarina; Frangež, Robert
Title		Spremljanje učinkov kainata z elektroencefalografijo in magnetnoresonančno tehniko slikanja radiofrekvenčnih električnih tokov
Translated title		Monitoring kainate activity using electoencephalography and magnetic resonance radio-frequency current density imaging
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 50, št. 3
Publication year		1999
Volume		str. 403-7
Language		slo
Abstract		Glutamate is the principal excitatory neurotransmitter in the mammalian central nervous system. The excessive activation of glutamate-operated ionic channels plays a major role in neuronal death associated with a range of neuronal disorders, including status epilepticus. Kainic acid is an excitatory glutaminergic agonist and a powerful epileptogenic agent. Direct delivery of kainate to the rat brain was used as an animal epilepsy model that was characterized using electroencephalographic measurements and radio-frequency current density imaging.
Summary		Glutamat je eden glavnih ekscitatornih nevrotransmiterjev v centralnem živčnem sistemu. Prekomerna aktivacija ionskih kanalčkov, ki jih nadzira glutamat, ima glavno vlogo pri nevronski smrti, ta pa je povezana s številnimi patološkimi stanji, tudi z epilepsijo. Kainska kislina je ekscitatorni glutaminergični agonist in močno epileptogeno sredstvo. Živalski model epilepsije, ki smo jo povzročili z direktnim vnosom kainata v podganje možgane, smo okarakterizirali z elektroencefalografskimi meritvami in slikanjem radiofrekvenčnih električnih tokov.
Descriptors		EPILEPSY KAINIC ACID BRAIN ELECTROENCEPHALOGRAPHY RATS ELECTRIC IMPEDANCE MAGNETIC RESONANCE IMAGING STATUS EPILEPTICUS DISEASE MODELS, ANIMAL