Author/Editor     Štiblar-Martinčič, Draga
Title     Morfološke značilnosti Langerhansovih celic
Translated title     Morphological characteristics of Langerhans cells
Type     članek
Source     Med Razgl
Vol. and No.     Letnik 39, št. 1
Publication year     2000
Volume     str. 79-83
Language     slo
Abstract     Langerhans cells are part of the widely distributed antigen-presenting cells known as dendritic cells with a key role in immune responses. These specialised bone marrow-derived cells were originally found in the epidermis and later demonstrated in the mucosa of other organs. Langerhans cells are difficult to identifiy in sections stained with hematoxylin-eosin. A large number of surface and/or cytoplasmic antigens have been localised on Langerhans cells for immunohistochemical detection. The Birbeck granules are the specific markers of Langerhans cells on electron microscopical level. Langerhans cells represent the primary immune defence of the skin and mucosae with various immunological functions, among which the processing and presenting antigen to T lymphocytes are the most important.
Summary     Langerhansove celice so del obsežnega sistema antigen predstavitvenih celic, znanih pod imenom dendritične celice, ki imajo osrednjo vlogo pri imunskem odzivu. Prvotno so te specializirane celice, ki imajo izvor v kostnem mozgu, našli v povrhnjici, kasneje pa so jih prikazali tudi v sluznici različnih organov. V preparatih, obarvanih s hematoksilinom in eozinom, so Langerhansove celice v svetlobnem mikroskopu težje prepoznavne, dokažemo pa jih imunohistokemično na osnovi številnih površinskih in/ali citoplazmatskih antigenov. Specifičen označevalec za prepoznavo na elektronskomikroskopski ravni so Birbeckova zrnca. Langerhansove celice omogočajo primarno predelavo in predstavitev antigena limfocitom T v koži in sluznicah.
Descriptors     LANGERHANS CELLS
BONE MARROW
EPIDERMIS
ANTIGEN-PRESENTING CELLS
T-LYMPHOCYTES
CYTOPLASMIC GRANULES
MICROSCOPY, ELECTRON
HEMATOXYLIN
MACROPHAGES