Author/Editor		Juetting, Uta; Gais, Peter; Rodenacker, Karsten; Boehm, Joachim; Hoefler, Heinz
Title		MIB-1, AgNOR and DNA distribution parameters and their prognostic value in neuroendocrine tumours of the lung
Type		članek
Source		Image Anal Stereol
Vol. and No.		Letnik 19, št. 1
Publication year		2000
Volume		str. 39-43
Language		eng
Abstract		One of the most important questions in clinical routine is to find out patients with good or worse prognosis to apply an optimal therapy scheme for each patient. In this study 58 patients with different neuroendocrine tumours of the lung were investigated. Histological sections were prepared with different stainings (MIB-1, AgNOR, Feulgen). By means of high resolution image cytometry stereological parameters were derived which are indicators for proliferation, ploidy and kinetics of the tumours. Cox regression analysis was calculated to test the significance of the parameters with regard to prognosis. The best parameter was MIB-1 which can easily be applied as a clinical standard staining and measurement.
Descriptors		LUNG NEOPLASMS NEUROENDOCRINE TUMORS PROGNOSIS SILVER STAINING NEOPLASM STAGING SURVIVAL ANALYSIS DNA IMAGE PROCESSING, COMPUTER-ASSISTED