Author/Editor		Pišljar, Marko; Denišlič, Miro; Meh, Duška
Title		Cognitive dysfunction and Parkinson's disease
Type		članek
Source		In: INABIS 2000. 6th internet world congress for biomedical science; 2000 Feb 14-25; La Mancha; Spain. La Mancha: Spanish society of health informatics,
Publication year		2000
Language		eng
Abstract		Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parkinson's disease, though the clinical picture of dementia is rarely reported. The development of cognitive deficits seams to be associated with hypokinesia and rigidity rather than tremor. In our study, auditory ERP were used to confirm cognitive alterations in two groups of non-demented patients with idiopathic Parkinson's disease. The mean duration of PD was 8.4 +- 4.2 years in the tremor group and 5.1 +- 3.8 years in the acinetic-rigidic group. Patients were classified according to the Hoehn-Yahr and Webster scale. The Beck depression score in Parkinson's patient was assessed. Auditory event related potentials were recorded using the "oddball" paradigm. The waves N100, P200, N200 and P300 were recorded and their latencies and amplitudes measured. The P3 latencies in both patients group were significantly longer (p<0,05), than in the control group. P3 latency was longer in non-tremor group. There were no significant statistical differences in latencies between the both groups. All patients had normal N1 latency. Significant decline of P3 amplitude was found only in non-tremor group (p<0,001).
Descriptors		PARKINSON DISEASE COGNITION DISORDERS MUSCLE RIGIDITY HYPOKINESIA PATIENT SELECTION EVOKED POTENTIALS, AUDITORY TREMOR