Author/Editor     Lunder, Tomaž
Title     Proučevanje izbranih spojin kot možnih ekcematogenih snovi pri bolnicah z rosaceo
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2000
Volume     str. 109
Language     slo
Abstract     Rosacea is a chronic inflammatory skin disorder. Not uncommonly, its course is characterised by acute episodes of deterioration precipitated by various external factors. Ointments are also known as possible provocating factors. Non-specific irritation of the skin was regarded as the principai mechanism of their possible influence in rosacea. However, the role of contact allergy to the constituents of ointments used for local treatment or skin care has not yet been clarified. Therefore, the aim of our study was to answer the question whether contact allergy to compounds in ointments is common in female patients with rosacea and whether it is involved in the episodes of deterioration of the disease. 100 randomly selected female patients with rosacea, attending the Department of Dermatovenereology, University Medical Centre Ljubljana, have been included in our study. The control group consisted of 100 female patients having non-ailergic skin disorders. The study of the problem of contact allergy was based on the analysis of patch test results at our department during the period 1989-1998. Among the various contact allergens of the standard test series, known to be present in ointments, we found fragrance compounds in the test preparation fragrance mix being the most common causative allergens. Furthermore, a striking increase in the frequency of positive reactions to fragrance mix has been noted during the last years. Therefore, we focused primarily on the role of contact allergy to fragrance compounds in female patients with rosacea. We evaluated the relevance of patch test results by a quantitative chemical analysis of the target fragrance compounds in the incriminated ointments using gas chromatography. Patch tests to the constituents of ointments and/or to ointments were positive in 24 % of patients with rosacea. (Abstract truncated at 2000 characters.)
Descriptors     ACNE ROSACEA
DERMATITIS, ALLERGIC CONTACT
OINTMENTS
COSMETICS
PATCH TESTS
ADMINISTRATION, TOPICAL
DRUG HYPERSENSITIVITY
METRONIDAZOLE
CLINDAMYCIN
NEOMYCIN
EUGENOL
IGG
HELICOBACTER PYLORI
CHROMATOGRAPHY, GAS