| Author/Editor | Hočevar, Marko | |
| Title | Uporabnost koncentracije tiroglobulina v serumu za diferencialno diagnostiko benignih in malignih folikularnih tumorjev ščitnice | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2000 | |
| Volume | str. 48 | |
| Language | slo | |
| Abstract | Background: There is no reliable diagnostic test for a preoperative differentiation between benign and malignant follicular and Hurthle cell neoplasms. Thyroglobulin, synthesized exclusively by normal or malignant thyrocytes, can be elevated in the se.ra of patients with benign as well as malignant thyroid disorders. The measurements of serum thyroglobulin (Tg) are therefore currently used only postoperatively as a marker of recurrent disease or distant metastases in the follow-up of patients with differentiated thyroid cancer. In this study, the preoperative serum Tg measurements were performed with the aim to investigate whether Tg levels differ in benign and malignant follicular and Hurthle cell neoplasms. Additionally, a possible influence of manual palpation and fine needle aspiration biopsy (FNAB) of the thyroid gland on serum Tg were evaluated. Patients and methods: In 516 patients who underwent thyroid surgery for clinical or cytological suspicious or malignant tumors at the Institute of Oncology in Ljubljana, Slovenia, from 1990 to 1996, the serum Tg concentration was measured in addition to the standard preoperative tests (FNAB, ultrasonography, 99mTc scanning and hormonal profile - at least TSH). After the operation, the patients were divided into 11 groups based on their histological diagnosis (papillary carcinoma classic variant, papillary carcinoma - follicular variant, papillary carcinoma - oncocytic variant, occult papillary carcinoma, follicular adenoma, follicular carcinoma, Hurthle cell adenoma, Hurthle cell carcinoma, anaplastic carcinoma, medullary carcinoma, nodular goiter) and the serum Tg values of these groups were compared. Additionally, in a group of 30 patients, serum Tg was measured immediately before manual palpation of the thyroid, 30 minutes after it, and again 30 minutes after FNAB. The measurements of all samples from each patient were performed in a single assay. (Abstract truncated at 2000 characters.) | |
| Descriptors | THYROID NEOPLASMS THYROGLOBULIN DIAGNOSIS, DIFFERENTIAL BIOPSY, NEEDLE CARCINOMA, PAPILLARY CARCINOMA, PAPILLARY, FOLLICULAR ADENOMA GOITER, NODULAR |