Author/Editor		Bertram, John F; Cahill, Meroe M
Title		Glomerular capillary growth and cellular hyperplasia in a model of focal and segmental glomerulosclerosis
Type		članek
Source		Image Anal Stereol
Vol. and No.		Letnik 19, št. 2
Publication year		2000
Volume		str. 109-12
Language		eng
Abstract		Focal and segmental glomerulosclerosis (FSGS) is a chronic renal disorder characterized by segmental glomerular lesions and widespread podocyte foot process effacement. We have previously shown that glomerular enlargement (hypertrophy) precedes the development of FSGS in an animal model not previously thought to involve glomerular hypertrophy. This hypertrophy involved growth of glomerular capillaries. The aim of the present study was to determine whether the capillary growth involved an increase in the number of capillaries per glomerulus, or lengthening of existing capillaries. In addition, we examined the contribution of glomerular cell hyperplasia to the hypertrophy. We found that glomerular capillary growth in this model appears to primarily involve lengthening of existing capillaries rather that sprouting of new capillaries, and that glomerular cell proliferation contributes to the glomerular hypertrophy.
Descriptors		GLOMERULOSCLEROSIS, FOCAL KIDNEY GLOMERULUS CAPILLARIES HYPERPLASIA HISTOLOGICAL TECHNIQUES PUROMYCIN AMINONUCLEOSIDE DISEASE MODELS, ANIMAL