Author/Editor		Rode, Mirela
Title		The role of saliva in the prevention of intraoral complications following irradiation
Translated title		Vloga sline pri preprečevanju intraoralnih zapletov po obsevanju
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 69, št. 4
Publication year		2000
Volume		str. 423-8
Language		eng
Abstract		Background. The aim of our study was to explain and estimate the effect of the parasympathomymetic pilocarpine and anticholinergic biperidene on the secretion and composition of saliva in patients with head and neck carcinoma and to evaluate their role in the prevention of irradiation side-effects in these patients. Our study is based on the hypothesis that in patients treated with irradiation for head and neck carcinoma, their glandular parenchyma can be successfuly protected against irradiation damages through inhibition of the parasympatheic system. After the irradiation treatment has been completed, the saliva production can be increased with stimulation of the parasympathetic system, which contributes to a decrease of the post-treatment xerostomia. Methods. 69 patients were randomly divided into three groups. A group patients received pilocarpine, B group patients received biperidene during their radiotherapy and pilocarpine afterwards, while C group patients received none of these medicaments as xerostomy prevention. The authors measured the quantities of saliva, the pH value and some salivary electrolytes. During the radiotherapy they also assesed the radiomucousitis degree. Results. Salivary secretion was the least affected in the group of patients who had been receiving biperidene. One year after radiotherapy had been finished, saliva could be measured only in these patients. During radiotherapy, a decrease of the pH value could be observed in all three groups of patients. (Abstract truncated at 2000 characters.)
Summary		Izhodišča. Namen naše raziskave je bil razjasniti in oceniti učinek parasimpatikomometika pilokarpina in antiholinergika biperidena na izločanje in sestavo sline pri bolnikih z rakom v področju glave in vratu in določiti njuno vlogo pri preprečevanju stranskih učinkov obsevalnega zdravljenja teh bolnikov. Raziskava je zasnovana na podmeni, da se lahko pri bolnikih, ki so obsevani zaradi raka v področju glave in vratu, z inhibicijo parasimpatika učinkovito zaščiti žlezni parenhim pred obsevalnimi poškodbami. Po končanem obsevalnem zdravljenju pa s stimulacijo parasimpatika lahko dosežemo povečano tvorbo sline, kar prispeva k zmanjšanju poobsevalne kserostomije. Metode. 69 bolnikov je bilo naključno razvrščenih v tri skupine. Bolniki v skupini A so prejemali pilokarpin, tisti v skupini B so prejemali med obsevalnim zdravljenjem biperidin in po obsevanju pilokarpin, bolniki v skupini C pa niso za zaščito pred kserostomijo prejeli nobenega od teh zdravil. Avtorji so merili količino sline, pH, in nekatere elektrolite v slini. Med obsevanjem so ocenili tudi stopnjo radiomukozitisa. Rezultati. Izločanje sline je bilo najmanj prizadeto pri skupini bolnikov, ki je prejemala biperidin. Eno leto po končanem obsevalnem zdravljenju je bilo slino mogoče meriti le pri teh bolnikih. (Izvleček prekinjen pri 2000 znakih.)
Descriptors		HEAD AND NECK NEOPLASMS XEROSTOMIA SALIVA SALIVATION PILOCARPINE BIPERIDEN