| Author/Editor | Šmid, Lojze; Zakotnik, Branko; Budihna, Marjan; Fajdiga, Igor; Lešničar, Hotimir; Šoba, Erika; Žargi, Miha | |
| Title | Pooperacijsko zdravljenje bolnikov z napredovalim karcinomom glave in vratu s kombinacijo obsevanja in kemoterapije | |
| Translated title | Postoperative treatment of advanced head and neck cancer patients with combination of radio- and chemotherapy | |
| Type | članek | |
| Source | Med Razgl | |
| Vol. and No. | Letnik 39, št. Suppl 3 | |
| Publication year | 2000 | |
| Volume | str. 19-21 | |
| Language | slo | |
| Abstract | This randomised clinical study compared the efficacy of two different types of postoperative treatment in patients operated on for advanced carcinoma in the head and neck region. Because of several unfavourable prognostic factors, a higher recurrence rate is expected in such patients. The patients were randomly assigned to receive postoperatively either radiotherapy alone (group A) or radiotherapy combined with simultaneous application of Mitomycin C and Bleomycin (group B). In group A, the disease recurred in 10/27 (37%) patients and in group B in 5/30 (17%). It appears on the basis of the results of this study that the group of patients who received combined postoperative treatment fared better than those treated by postoperative radiotherapy alone. | |
| Summary | V prospektivni randomizirani klinični študiji primerjamo uspešnost dveh vrst pooperacijskega zdravljenja bolnikov, pri katerih je bilo zaradi neugodnih napovednih dejavnikov z večjo verjetnostjo pričakovati ponovitev karcinoma v področju glave in vratu. Glede na način pooperacijskega zdravljenja smo bolnike po načinu naključnega izbora delili v skupino, kjer so bili bolniki le obsevani (skupina A), ali v skupino, kjer so poleg obsevanja sočasno prejemali še Mitomicin C in Bleomicin (skupina B). V skupini bolnikov, zdravljenih samo s pooperacijskim obsevanjem, se je bolezen ponovila pri 10/27 (37 %) bolnikih, v skupini bolnikov, zdravljenih s sočasno kemoterapijo in obsevanjem, pa pri 5/30 (17 %). Prikazani rezultati nakazujejo boljši učinek pooperacijskega zdravljenja s hkratno kemoterapijo in obsevanjem v primerjavi s samim obsevanjem. | |
| Descriptors | HEAD AND NECK NEOPLASMS POSTOPERATIVE CARE BLEOMYCIN MITOMYCIN C TREATMENT OUTCOME |