| Author/Editor | Strojan, Primož; Budihna, Marjan; Šmid, Lojze; Svetic, Branka; Vrhovec, Ivan; Kos, Janko; Škrk, Janez | |
| Title | Cistatini - endogeni zaviralci cisteinskih proteinaz: njihov pomen za napoved izida bolezni pri bolnikih s ploščatoceličnim karcinomom glave in vratu | |
| Translated title | Cystatins - endogenous inhibitors of cysteine proteinases: their prognostic significance in patients with squamous cell carcinoma of the head and neck | |
| Type | članek | |
| Source | Med Razgl | |
| Vol. and No. | Letnik 39, št. Suppl 3 | |
| Publication year | 2000 | |
| Volume | str. 81-5 | |
| Language | slo | |
| Abstract | Purpose: To evaluate the prognostic significance of cysteine proteinase inhibitors of the cystatin superfamily - stefins A and B (SA, SB) and cystatin C (CC) - in squamous cell carcinoma of the head and neck. Patients and Methods: Concentrations of SA, SB and CC: were measured in samples of tumour cytosol and serum from 90 or 35/90 patients, respectively. Results: Higher levels of all the three inhibitors correlated significantly with longer disease-free survival (DFS) in our patients. Multivariate analysis showed SA to be the most important independent prognostic factor for DFS. No correlation was observed between the serum levels of studied inhibitors and survival of the patients. Conclusion: The results of our study indicate that the cytosol levels (but not also the serum levels) of SA - and to a lesser degree also of SB and CC - could be of prognostic significance in this particular type of cancer. | |
| Summary | Namen: Preučiti napovedni pomen zaviralcev cisteinskih proteinaz iz naddružine cistatinov-stefinov A in B ter cistatina C - pri ploščatoceličnem karcinomu glave in vratu. Bolniki in metode: Koncentracije stefinov A in B ter cistatina C smo izmerili v vzorcih citosola tumorskega tkiva ter seruma pri 90 oz. 35/90 bolnikih. Rezultati: Večje vrednosti vseh treh zaviralcev so napovedovale daljše preživetje brez bolezni pri naših bolnikih. V multivariatni analizi se je stefin A izkazal kot najpomembnejši neodvisni dejavnik za napoved preživetja brez bolezni. Med serumskimi vrednostmi preučevanih zaviralcev in preživetjem bolnikov nismo zabeležili nikakršne povezanosti. Zaključek: Rezultati naše raziskave kažejo, da utegnejo citosolne vrednosti stefina A (ne pa tudi serumske) - v manjši meri tudi stefina B oz. cistatina C - pri tej vrsti raka napovedovati izid bolezni. | |
| Descriptors | HEAD AND NECK NEOPLASMS CARCINOMA, SQUAMOUS CELL CYSTATINS PROGNOSIS SURVIVAL ANALYSIS CYTOSOL |