Author/Editor		Rode, Mirela; Šmid, Lojze; Rode, Matjaž; Budihna, Marjan
Title		Izločanje sline med obsevanjem in po njem
Translated title		Salivary flow rate during and after radiotherapy
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 39, št. Suppl 3
Publication year		2000
Volume		str. 87-9
Language		slo
Abstract		The aim of the present study was to explore and evaluate the effects of parasympathomimetic pilocarpine and anticholinergic biperiden on the secretion and composition of saliva in patients with malignant tumours of the head and neck during radiotherapy. A study was carried out on a series of 69 patients who were randomised into three groups. Group A consisted of patients receiving pilocarpine, Group B of those receiving biperiden during radiotherapy and pilocarpine for six weeks after its completion, and Group C patients not receiving any xerostomy prevention therapy during or after radiotherapy. The quantity of secreted saliva was measured before the beginning of therapy, after a dose of 30 Gy of radiation, on completion of irradiation, and 3, 6 and 12 months after completion of radiotherapy. Six months after the completion of radiotherapy, the differences in the quantity of secreted saliva between groups C and B as well as between groups A and B were found to be statistically significant (P = 0.002 and 0.05 respectively). It seems that the inhibition of saliva production during radiotherapy and stimulation after the completion of radiotherapy may contribute to the preservation of salivary gland function after therapy.
Summary		Avtorji so želeli proučiti in ovrednotiti učinkovitost parasimpatikomimetika pilokarpina ter antiholinergika biperidena na izločanje in sestavo sline pri bolnikih z rakom glave in vratu, zdravljenih z obsevanjem. V raziskavo so uvrstili 69 bolnikov, ki so jih razdelili v tri skupine. V skupino A so uvrstili bolnike, ki so prejemali pilokarpin, v skupino B tiste, ki so med obsevanjem prejemali biperiden in po obsevanju še šest tednov pilokarpin, v skupino C pa so uvrstili bolnike, ki niso prejemali zdravil za preprečitev kserostomije med obsevanjem in po njem. Količino izločene sline so merili pred začetkom zdravljenja, po prejetih 30 Gy, po končanem obsevanju ter 3, 6 in 12 mesecev po zaključku obsevanja. Šest mesecev po končanem obsevanju je bila razlika v izločanju sline med skupinama C in B in skupinama A in B statistično značilna (P = 0,002 in 0,05). Avtorji zaključujejo, da inhibicija izločanja sline med obsevanjem in stimulacija po njej vpliva na ohranitev funkcije žleze slinavke po obsevanju.
Descriptors		HEAD AND NECK NEOPLASMS SALIVATION PILOCARPINE BIPERIDEN XEROSTOMIA SALIVARY GLANDS PARASYMPATHETIC NERVOUS SYSTEM