Author/Editor		Skalerič, U
Title		Neantibiotično delovanje tetraciklinov in uporaba v parodontologiji
Translated title		Non-antibiotic properties of tetracyclines and their use in periodontology
Type		članek
Source		Zobozdrav Vestn
Vol. and No.		Letnik 55, št. 2-3
Publication year		2000
Volume		str. 73-7
Language		slo
Abstract		Seminal experiments of Golub and coworkers demonstrated that tetracyclines inhibit matrix metalloproteinases and thus influence the breakdown of connective tissue and bone. This discovery led to the development of a formulation containing a subantimicrobial dose of doxycyclin (Periostat) and its use in patients with moderate and advanced periodontitis. The first multicentric study of Periostat therapy used as an adjunct to scaling and root planing showed significant improvement of clinical attachment and reduction of probing depth in treated patients. Further research and development of chemically modified tetracyclines with non-antibiotic properties will open new possibilities for the treatment of periodontal disease and other systemic disorders affecting the breakdown and restoration of connective tissue and bone.
Descriptors		PERIODONTITIS TETRACYCLINES ANTIBIOTICS ANTIMALARIALS ANTINEOPLASTIC AGENTS BONE RESORPTION CONNECTIVE TISSUE DOXYCYCLINE DENTAL SCALING METALLOPROTEINASES