| Author/Editor | Pinter, Bojana | |
| Title | Polimorfizem gena za receptor vitamina D in spremembe metabolizma kosti ob jemanju kombinirane oralne hormonske kontracepcije | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2000 | |
| Volume | str. 66 | |
| Language | slo | |
| Abstract | Background Combined oral contraception is one of the most frequently used and also most evaluated contraceptive methods. Several studies report on the beneficial effect of combined oral contraception on bone metabolism in premenopausal women and on the reduced risk for the development of postmenopausal osteoporosis in past oral contraceptive users. However, the influence of combined oral contraceptives on bone metabolism in younger women, especially the influence on the acquiring peak bone mass, has not been clarified yet. The peak bone mass is mostly determined by genetic factors. The major genetic determinant of bone metabolism and bone mass known by now is vitamin D receptor (VDR) gene. The aim of this study was to determine whether bone metabolism in women aged 20-27 years was influenced by oral contraceptives and whether the influence was related to the VDR gene polymorphism. Methods In the prospective clinical study, 41 healthy women, aged 20-27 years, were included. Twenty-one women in the study group were prescribed a combined oral contraceptive in a daily dose of 30 micro g ethinyl estradiol and 150 micro g levonorgestrel. Twenty women in the control group were prescribed a non-hormonal contraceptive or none, if not wanted. In the beginning of the study and after three months, the biochemical markers of bone metabolism were evaluated in all the women enrolled in the study: serum bone alkaline phosphatase, serum osteocalcin, urinary calcium/creatinine, total urinary pyridinoline and deoxypyridinoline and pure urinary deoxypyridinoline. Vitamin D receptor gene polymorphism was determined by Restriction Fragment Length Polymorphism (RFLP) analysis using BsmI endonuclease. In the statistical analysis of the women's characteristics t-test and test X2 were used. (Abstract truncated at 2000 characters) | |
| Descriptors | CONTRACEPTIVES, ORAL, COMBINED BONE DENSITY POLYMORPHISM (GENETICS) RECEPTORS, CALCITRIOL PROSPECTIVE STUDIES BONE AND BONES ALKALINE PHOSPHATASE OSTEOCALCIN CALCIUM PYRIDONES POLYMORPHISM, RESTRICTION FRAGMENT LENGTH OSTEOPOROSIS |