Author/Editor     Legan, Matejka
Title     Rastni hormon pri funkcionalni androgenizaciji
Translated title     Growth hormone in functional hyperandrogenism
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2000
Volume     str. 56
Language     slo
Abstract     Insulin resistance and hyperinsulinism are now well recognized features of obese women witl functional hyperandrogenism (FH) and accepted pathogenetic factor of disorder in obese patients Non-obese women with FH have less expressed insulin resistance and higher serum growth hormone (GH) concentrations. Our hypothesis was that GH and peripheral markers of its influence (IGF-I, GHBP, IGFBP-3) correlate importantly with degree of androgenemia (concentrations of serum androgens) as well as with other characteristics (higher bone mineral density) in non-obese women with FH. In prospective clinical study, eighteen androgenized women were enrolled, aged 18 to 35 years of normal body weight (within +/- 20 % according to Metropolitane Life Inssurance Tables) with clinical signs of hyperandrogenism (hirsutism and/or acne and/or androgenic alopecia) and increased serum concentration of at least one of determined serum androgens. Ten of them were eumenorrhoeic, 8 oligomenorrhoeic. Other endocrinological diseases with androgen excess were excluded. Ten healthy eumenorrhoeic counterparts (age and weight matched) formed a control group. In the early follicular phase a blood sample was obtained for determinating plasm; concentrations of free testosterone (FT), androstendione (A), dehydroepiandrosterone sulphate (DHEAS) and estradiol (E2). On random day each participant passed growth hormone releasing hormone test (GHRH test) with basal and consecutive determinations of GH during stimulation During GHRH test we also assesed serum concentrations of insulin (IRI), insulin-like growtl factor-I (IGF-I), glucose (G), IGF-binding protein-1 (IGFBP-1), IGF-binding protein-3 (IGFBP-3) and GH-binding protein (GHBP). Each participant BMD of lumbar spine (L2 - L4) wa meassured by dual X-ray absorptiometry method. (Abstract truncated at 2000 characters).
Descriptors     HIRSUTISM
ANDROGENS
ACNE VULGARIS
ALOPECIA AREATA
BONE DENSITY
ANTHROPOMETRY
INSULIN RESISTANCE
TESTOSTERONE
ANDROSTENEDIONE
DEHYDROEPIANDROSTERONE SULFATE
ESTRADIOL
INSULIN
INSULIN-LIKE GROWTH FACTOR I
BLOOD GLUCOSE
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3