Author/Editor		Zidar, Nina; Volavšek, Metka; Trček, Ciril; Kern, Izidor; Gale, Nina
Title		Wegener's granulomatosis in the upper respiratory tract
Type		članek
Source		Wien Klin Wochenschr
Vol. and No.		Letnik 112, št. 15-16
Publication year		2000
Volume		str. 676-9
Language		eng
Abstract		Wegener's granulomatosis is a distinct clinico-pathological entity characterised by necrotising vasculitis of small arteries and veins in conjunction with the formation of granuloma in the upper and lower respiratory tracts, and glomerulonephritis. The vast majority of patients have antineutrophil cytoplasmic antibodies in the serum with a characteristic cytoplasmic pattern. However, in early phases of the disease only the upper respiratory tract may be affected, clinical and histological features may be nonspecific, and antineutrophill cytoplasmic antibodies not present. In this paper we present four patients with involvement of the upper respiratory tract suspicious for early Wegener's granilomatosis. We emphasise the significance of clinical, histopatological and serological parameters in the early detection of Wegener's granulomatosis.
Descriptors		WEGENER'S GRANULOMATOSIS RESPIRATORY TRACT DISEASES AGED ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC GLOMERULONEPHRITIS BIOPSY