Author/Editor		Pečovnik-Balon, Breda
Title		Utjecaj vitamina 1,25(OH)2D3 na sekundarni hiperparatireoidizam u dijaliziranih bolesnika
Type		monografija
Place		Zagreb
Publisher		Sveučilište u Zagrebu, Medicinski fakultet
Publication year		1994
Volume		str. 69
Language		cro
Abstract		When glomerular filtration drops to 25% of its normal value, the concentration of phosphates in blood begins to rise. The consequence is a decrease in the concentration of ionized calcium in blood as well as an increase in the synthesis and release of parathormone from the parathyroid glands. With the decrease of the kidney tissue mass, calcitriol synthesis decreases also. The consequence is an increase in parathormone secretion affecting the bones. Our prospective one-year study comprises 93 patients of both sexes, various ages and various dialysis duration. From among them 31 patients with a concentration of Ca in blood under 2,7 mmol/l, a concentration of P under 1,8 mmol/1 and a concentration of PTH; over 65 pg/ml (group 0) received calcitriol 0,25 čg/day. The control group consisted of patients not receiving calcitriol. One group had normal Ca and P metabolism (group 1), the other had disturbed Ca and P metabolism (group 2). A comparison of average plasmic concentrations of Ca, P, AP, PTH; and X-ray changes in the various groups at the beginning of the investigation and one year later was carried out. The entire population was also divided according to dialysis location and normality of Ca and P metabolism. At the begining of the treatment the average P concentration was statistically significantly higher in group 2 (P<0,005) as compared to group 0. At the beginning of treatment the average Ca concentration was statistically significantly lower in group 0 as compared to group 2 (P<0,001) and in group 0 as compared to group 1 (P<0,005). At the termination of the one-year treatment, when compared to the initial state, a statistically significant increase in the concentration of Ca (P<0,005) and in the concentration of P (P<0,005) was noted in group 0. (Abstract truncated at 2000 characters.)
Descriptors		HEMODIALYSIS HYPERPARATHYROIDISM, SECONDARY CALCITRIOL CALCIUM PHOSPHORUS PARATHYROID HORMONES TIME FACTORS