Author/Editor		Polenaković, M
Title		Natural history and treatment of membranous nephropathy
Type		članek
Source		In: Lindič J, Kaplan-Pavlovčič S, editors. Zbornik prispevkov 1. slovenski nefrološki kongres z mednarodno udeležbo; 1996 okt 23-26; Portorož. Ljubljana: Klinični center, Nefrološka klinika,
Publication year		2000
Volume		str. 15-21
Language		eng
Abstract		Membranous nephropathy is an immune-complex mediated disease, well defined histopathologically and clinically, but with unpredictable course of the disease. The aim of this study was to present natural course of idiopathic membranous nephropathy and influence of the treatment. Among our biopsied patients we selected 58, 36 male and 22 female, aged 33.2 +- 11.5 who were not treated or their treatment can be neglected to present the natural course of the disease. On the other hand, to present the response to therapy, we selected 39 patients with stage II of the disease, all nephrotic treated on different ways. They were divided in 4 groups: 10 without treatment, 13 treated with steroids, 13 treated with chlorambucil and steroids and 3 treated with cyclosporine. We noted 5 different outcomes of the disease in patients with membranous nephropathy: 1) long remissions, 2) relapsing disease, 3) slow progressive disease, 4) rapid progression and 5) relapsing nephrotic syndrome and renal failure. Patients treated with steroids presented sigificant decrease of proteinuria (p 0.01), and also the patients treated with steroids and chlorambucil (p 0.05). It was not noted in control subjects and in cases treated with cyclosporine. Treated patients presented lower incidence of chronic renal failure compared with controls. We can conclude that natural course of the disease is unpredictable and our treated patients with the same histopathological degree present significant decrease of proteinuria and lower incidence of development of chronic renal failure during follow-up. (Abstract truncated at 2000 characters.)
Descriptors		GLOMERULONEPHRITIS, MEMBRANOUS BIOPSY METHYLPREDNISOLONE PREDNISONE CYCLOSPORINE FOLLOW-UP STUDIES TREATMENT OUTCOME NEPHROTIC SYNDROME PROTEINURIA HYPERTENSION KIDNEY FAILURE