Author/Editor		Zitta, S; Stoschitzky, K; Lang, T; Zweiker, R; Holzer, H; Lanzer, G; Reibnegger, G; Mayer, F; Estelberger, W
Title		A new method for the assessment of renal reserve capacity in hypertensives and renal transplant recipients
Type		članek
Source		In: Lindič J, Kaplan-Pavlovčič S, editors. Zbornik prispevkov 1. slovenski nefrološki kongres z mednarodno udeležbo; 1996 okt 23-26; Portorož. Ljubljana: Klinični center, Nefrološka klinika,
Publication year		2000
Volume		str. 99-104
Language		eng
Abstract		Dynamic renal function tests for the investigation of changes in renal function due to dietary agents are investigated. For this purpose two singleshot experiments using sinistrin together with p-aminohippuric acid as (p-AH) clearance markers, and proteins as dietary factor at the beginning of the second experiment are performed. The procedure was applied to normal controls, moderately hypertensive patients with normal serum creatinine, and renal transplant recipients (Tx patients). The glomerular filtration rates (GFR) rise in normal test subjects under the influence of protein loads. In each of the two patient collectives, however, one group shows higher or at least the same GFR values, whereas another group exhibits significant decreases of the glomerular filtration rates following the protein test meal. In the Tx patients the group responding with increases or at least constancy in glomerular filtration consists of normotensive, whereas the other one exhibiting 'paradoxical' decreases in GFR comprises mainly hypertensive patients. Since the moderately hypertensive patients were in the washout phase of standard antihypertensive medication, as also applied to the Tx patients, the clearance responses to the dietary loads are obviously correlated with long-term effects of increased blood pressures. Both decreased and normal values of GFR occured in the first experiments in both of the two groups of both patient collectives. (Abstract truncated at 2000 characters.)
Descriptors		GLOMERULAR FILTRATION RATE HYPERTENSION RENAL CIRCULATION DIABETIC NEPHROPATHIES DIETARY PROTEINS KIDNEY TRANSPLANTATION ANTIHYPERTENSIVE AGENTS