Author/Editor     Pečovnik-Balon, B; Zavratnik, A
Title     Zmanjšana kostna gostota izmerjena s kvantitativno digitalno radiografijo (QDR) pri bolnikih s končno ledvično odpovedjo ob začetku hemodializnega zdravljenja
Type     članek
Source     In: Lindič J, Kaplan-Pavlovčič S, editors. Zbornik prispevkov 1. slovenski nefrološki kongres z mednarodno udeležbo; 1996 okt 23-26; Portorož. Ljubljana: Klinični center, Nefrološka klinika,
Publication year     2000
Volume     str. 191-7
Language     slo
Abstract     The aim of the study was to establish bone density in patients beginning replacement treatment with hemodialysis, the differences between cortical bone density (BMDc) and trabecular bone density (BMDt), a possible association with the duration of renal failure prior to the introduction of replacement hemodialysis treatment and the concentration of intact parathormone (PTHi) in serum. Our prospective clinical study included 21 patients who had begun replacement hemodialysis treatment at Maribor Teaching Hospital between 1994 and 1995. Their average age was 51 +- 13 years. Bone density (BMD) was measured on the femoral neck as a measure of BMDc and in the lumbar spine region as a measure of BMDt. Average BMDt was 0.88 +- 0.19 g/cm2 (male: 0.97 +- 0,17 g/cm2, female: 0.72 +- 0.12 g/cm2); average BMDc was 0.73 +- 0.22 g/cm2 (male: 0.79 +- 0.23 g/cm2 female: 0.60 +- 0.10 g/cm2) meaning an average 94 +- 24% BMDc of healthy individuals of corresponding age and sex. A negative correlation exists between the duration of renal affection prior to introduction of dialysis treatment and BMDt (p < 0.05) as well as BMDc (p < 0.05). There is also a statistically significant difference between BMDt in men and women (p < 0.005) and BMDc in men and women (p < 0.05). But there are no differences in patient age, duration of renal affection prior to dialysis treatment, PTHi concentration, and all patients had normal serum electrolyte concentrations. Serum A1 concentrations were under 100 microg/L. Conclusions: - At the beginning of dialysis treatment there were no differences between BMDt and BMDc. - A negative correlation exists between the duration of renal affection prior to the introduction of replacement therapy and BMDt (p < 0.05) as well as BMDc (p < 0.05). - BMDt and BMDc are statistically significantly lower in women - BMDt (p < 0.005), BMDc (p < 0.05). - There is no statistically significant correlation between BMD and PTHi.
Descriptors     KIDNEY FAILURE, CHRONIC
HEMODIALYSIS
RENAL OSTEODYSTROPHY
HYPERPARATHYROIDISM, SECONDARY
OSTEOMALACIA
BONE DENSITY
CALCIUM
PHOSPHORUS
PARATHYROID HORMONES