Author/Editor		Varl, J; Bren, A; Kandus, A
Title		Iron substitution during epoetin alfa and epoetin omega therapy
Type		članek
Source		In: Buturović-Ponikvar J, Bren AF, editors. Zbornik 2. slovenski nefrološki kongres z mednarodno udeležbo ob 30. letnici dialize in transplantacije ledvic v Sloveniji; 2000 sep 27-30; Brdo pri Kranju. Ljubljana: Klinični center, Klinični oddelek za nefrologijo,
Publication year		2000
Volume		str. 219-22
Language		eng
Abstract		Background. The aim of the study was to evaluate the efficiency of i. v. iron substitution during rHu EPO therapy and to determine the influence of epoetin alfa and epoetin omega on iron levels. Methods and patients. 38 chronic hemodialysis patients, 19 males and 19 females, were treated 6 months with epoetin alfa (group A) and 6 months with epoetin omega (group B). Iron was supplemented intravenously as ferric saccharate (100 mg) after HD treatment in both groups. Results. In group A, 100 mg of iron were given semi-monthly in 22 pts, monthly in 10 pts and less frequently in 6 pts. In group B, iron was given semi-monthly in 23 pts, monthly in 9 pts, less frequently in 5 pts, one pt needed no substitution. There was no significant difference in the iron supplementation: mean 926 mg +- 414 mg SD (group A), mean 784 +- 352 mg SD (group B). Transferrin saturation was mean 25 +- 8% SD (group A), mean 26 +- 8% SD (group B), NS. Ferritin was mean 406 +- 145 ng/ml SD (group A), mean 388 +- 126 ng/ml SD (group B), NS. Serum iron was mean 11,7 +- 3,8 mol/L SD (group A), mean 11,4 +- 3,5 mol/L SD (group B), NS. There were no side effects during iron application. Conclusions. i.v. application of ferric saccharate was efficient and save. Semi monthly or monthly dose of 100mg of iron was enough in majority of pts to keep the levels of ferritin and transferrin saturation in desired levels.There were no statistical differences between group A nad group B. Both types of epoetins needed the same amount of iron to sustain the target hemoglobin values.
Descriptors		HEMODIALYSIS EPOETIN ALFA IRON IRON, DIETARY ANEMIA