Author/Editor		Ponikvar, Rafael; Urbančič, Alenka; Buturović-Ponikvar, Jadranka
Title		Residual renal function and renal ultrasound in chronic hemodialysis patients: synthetic vs. cuprophan membrane
Type		članek
Source		In: Buturović-Ponikvar J, Bren AF, editors. Zbornik 2. slovenski nefrološki kongres z mednarodno udeležbo ob 30. letnici dialize in transplantacije ledvic v Sloveniji; 2000 sep 27-30; Brdo pri Kranju. Ljubljana: Klinični center, Klinični oddelek za nefrologijo,
Publication year		2000
Volume		str. 269-73
Language		eng
Abstract		Initiation of the dialysis causes a further decline of residual renal function. The aim of the prospective clinical study was to assess the impact of the dialysis membrane on the decline of residual urine volume and whether it is associated with sonographicaly detectable differences of the kidney. 42 patients starting hemodialysis (HD) from February 1996 to March 1998, were allocated to the treatment with synthetic (polyacrilonitril, polysulphone - group A: n=27 (64%)) or cuprophane (group B: n=15 (36%)) membrane. Hydration status was evaluated and kidney ultrasound was performed at the start of HD; residual urine volume (RUV), blood pressure, body weight, treatment time were reevaluated after 1, 3, 6, 12, 18 and 24 months. At the start of HD 32 pts (76.2 %) have more than 500 ml of RUV per day. Mean RUV was 1009 +- 558 ml in group A and 1233 +- 758 ml in group B (ns). In both groups RUV was markedly reduced during the observation time, being larger in group A, the difference between groups was statistically significant in 1st, 3rd, 6th and 12th month, when RUV was 940 +- 336 ml in group A and 367 +- 306 ml in group B (p=0.5). There were no statistically significant differences found between groups A and B in ultrasound parameters. Treatment time was similar in both groups in 1st, 3rd and 6th months, but in 12th month it was 8.7 hours/week in group A and 12.5 hours/week in group B (p=0.003). Our results revealed better preserved residual renal function in patients dialysed with synthetic membranes, which might have an impact on reducing the weekly treatment time. No ultrasound detectable changes were found between the two groups to be able to explain that observation. Whether this is related to biocompatibility of synthetic membranes, needs to be further investigated.
Descriptors		HEMODIALYSIS KIDNEY FUNCTION TESTS KIDNEY FAILURE MEMBRANES, ARTIFICIAL