Author/Editor		Ponikvar, R; Buturović-Ponikvar, J
Title		Blood purification in septic shock
Type		članek
Source		In: Buturović-Ponikvar J, Bren AF, editors. Zbornik 2. slovenski nefrološki kongres z mednarodno udeležbo ob 30. letnici dialize in transplantacije ledvic v Sloveniji; 2000 sep 27-30; Brdo pri Kranju. Ljubljana: Klinični center, Klinični oddelek za nefrologijo,
Publication year		2000
Volume		str. 279-83
Language		eng
Abstract		Various blood purification methods have been used to treat septic shock. Hemodialysis and continuous renal replacement therapies remove endotoxin and cytokines from blood predominantly by adsorption to synthetic membrane but unfortunately without important clinical effect. Effect of charcoal hemoperfusion was based only on nonrandomized animal models and because of lack of clinical experience it is difficult to accept it as a therapy of septic shock. Polymyxin B bound to polystyrene insoluble fiber hemoperfusion have had impressive clinical results both in animal as well as in clinical studies but is still in the phase of clinical trial. Monoclonal antibodies against endotoxin were not useful and further work on this field should be done. On the other hand, plasma exchange with fresh frozen plasma as a replacement solution have been effective in improving mortality rate among patients with septic shock. However, these studies were not controlled.
Descriptors		SHOCK, SEPTIC PLASMA EXCHANGE HEMODIALYSIS POLYMYXIN B RENAL REPLACEMENT THERAPY