Author/Editor		Černe, Darko; Kaplan-Pavlovčič, Staša; Kranjec, Igor; Jurgens, Gunther
Title		Mildly elevated serum creatinine concentration correlates with the extent of coronary atherosclerosis
Type		članek
Source		In: Buturović-Ponikvar J, Bren AF, editors. Zbornik 2. slovenski nefrološki kongres z mednarodno udeležbo ob 30. letnici dialize in transplantacije ledvic v Sloveniji; 2000 sep 27-30; Brdo pri Kranju. Ljubljana: Klinični center, Klinični oddelek za nefrologijo,
Publication year		2000
Volume		str. 337-42
Language		eng
Abstract		Background: Mildly elevated serum creatinine concentration was proposed to be a marker for increased risk of cardiovascular disease mortality. The aim of our prospective study was to evaluate a possible association between serum creatinine concentration and extent of coronary atherosclerosis together with conventional risk factors for atherosclesosis. Methods: We measured creatinine concentration in serum in 40 male patients without overt renal or ischemic renal disease (mean age 53 +- 7 years) with stable or unstable angina undergoing routine coronary arteriography. Extent of coronary atherosclerosis was assessed by Gensini score. Results: In univariate linear regression analysis Gensini score significantly correlated with serum concentrations of apolipoprotein All (r = - 0.3242, P < 0.05) and creatinine (r = +0.3194, P < 0.05), but not with serum concentrations of lipids (total, low- and high-density lipoprotein cholesterol, triglycerides), other apolipoproteins (apo B, apo AI), lipoprotein(a), or age, weight and status of smoking, diabetes or hypertension. Multivariate linear regression analysis revealed that elevated serum creatinine was associated with the extent of coronary atherosclerosis independently of conventional risk factors for atherosclerosis. Conclusion: Mildly elevated serum creatinine was probably the marker of generalised vascular disease denoting early nephrovasculopathy in correlation with established atherosclerotic risk factors.
Descriptors		CORONARY ARTERIOSCLEROSIS CREATININE CORONARY ANGIOGRAPHY LIPIDS APOLIPOPROTEINS BODY MASS INDEX