Author/Editor		Peharda, V; Gruber, F; Kaštelan, M; Brajac, I; Čabrijan, L
Title		Pruritus an important symptom of internal diseases
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 9, št. 3
Publication year		2000
Volume		str. 92-104
Language		eng
Abstract		Pruritus is a common unpleasant sensation, accompanied frequently by scratching. This symptom can be caused by numerous cutaneous diseases and by internal disorders. Pruritus is mediated by histamine, proteases, prostaglandins, and substance P. The biochemical, cellular mechanisms and the neuroanatomical pathway which determine the outbreak of pruritus in different internal diseases are described. The exact diagnosis is important for choosing an appropriate treatment.
Descriptors		PRURITUS INTERNAL MEDICINE UREMIA CHOLESTASIS NEOPLASMS HISTAMINE PROSTAGLANDINS SUBSTANCE P