Author/Editor		Simonič, Igor; Stanovnik, Branko
Title		Priprava novih Hantzschevih estrov s potencialno aktivnostjo
Type		članek
Source		In: Glavič P, Brodnjak-Vončina D, editors. Zbornik referatov s posvetovanja Slovenski kemijski dnevi 2000: 1. in 2. del; 2000 sep 28-29; Maribor. Maribor: FKKT,
Publication year		2000
Volume		str. 125-30
Language		slo
Abstract		Amines (2) prepared by hydrogenation of dimethyl or ethyl methyl 2.6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates (1) were formylated to dimethylaminomethyleneamines (3) or amidines (5). Conversion of 3 with hippuric or aceturic acid gave methyleneoxazolones 6 which with alcoholates formed esters 7 or 8. Reaction with different amines did not take place to amides but oxazolonemethyleneamines 9. Amines 2 reacted with N,N-dimethylaminoetenes 11 to yield compounds 12 or 13 which are analogues of compounds 7 and 8. Compounds 12 and 13 were isolated as mixtures of E and Z isomers, but analyses manly showed prevailing amounts of E isomers. Acetylation of amine 2 gave mono (14) or diacetylic (15) derivatives. The lasts were prepared by acetylation of compound 3a as well. The compounds prepared in that manner have potential Ca antagonistic activity.
Descriptors		DIHYDROPYRIDINES ACETYLATION DRUG INDUSTRY CHEMISTRY, PHARMACEUTICAL