Author/Editor | Tripkovič, M; Kozjek, F; Križman, I; Jereb, J; Francetič, I; Grabnar, I; Mrhar, A | |
Title | Effects of ondansetron on portal hemodynamics in liver cirrhosis | |
Type | članek | |
Source | Clin Pharmacol Ther | |
Vol. and No. | Letnik 38, št. 9 | |
Publication year | 2000 | |
Volume | str. 436-40 | |
Language | eng | |
Abstract | Objective: The double-blind randomized pilot study was undertaken to compare the effects of a 10-day course of ondansetron 8 mg/day and propranolol 80 mg/day perorally in treating portal hypertension. Subjects and methods: 16 patients with liver disease were enrolled in the study. Measurements of portal vein diameter, portal blood flow velocity and portal blood flow volume were done at days 1, 5 and 10 of treatment using duplex Doppler sonography. Results: The propranolol group demonstrated a decrease in portal venous diameter, while patients treated with ondansetron exhibited reduced portal blood flow velocity values. A decreased portal blood flow volume was found in both groups after 10 days of therapy. Conclusion: No statistically significant differences were found between the groups with the exception of portal venous diameter which is significantly lower at the end of the treatment in the case of propranolol. | |
Descriptors | LIVER CIRRHOSIS PROPRANOLOL ONDANSETRON HYPERTENSION, PORTAL PORTAL VEIN BLOOD FLOW VELOCITY ESOPHAGEAL AND GASTRIC VARICES ULTRASONOGRAPHY, DOPPLER, DUPLEX |