Author/Editor		Honzak, Lidija; Šentjurc, Marjeta
Title		Development of liposome encapsulated clindamycin for treatment of acne vulgaris
Type		članek
Source		Pflugers Arch
Vol. and No.		Letnik 440, št. 5 Suppl
Publication year		2000
Volume		str. R44-5
Language		eng
Abstract		The enhancement of topical delivery of hydrophilic substances by use of multilammelar liposomes was measured ex vivo on pig ear skin and in vivo on hairless mice by electron paramagnetic resonance method (EPR) Multilamellar liposomes with different lipid composition (final concentration of membrane components is 48 mg/ml) were loaded with a hydrophilic spin probe GluSL, which does not penetrate the liposome membane easily. They were cheaclerized with respect to their slability, entrapped vulume and enhancement characteristics. We observed significant difierences in the pruperties of dilferent types of liposomw with rcspect to their stability when in conlact with the skin and fheir penetration intn the skin. 'fhe results measured in vivo arc consistent with those obtained cx vivo. On the basis of these findings the liposomes with appropriate stability and intradermal penetration characteristics were chosen for the developmem of liposome-encapsulated 1% clindamycin preparation for therapy of acne vulgaris. A double-blind clinical study was conducted to assess the safety and efficiency of liposome-encapsulated 1% clindamycin solution versus 1% clindamycin solution (Klimicin T, Lek). On the basis of the clinical trial or may be concluded thal liposome-encapsulared 1% clindamycin solution was therapeutically superior ever conventional 1% clindamycin solution in the treatment of acne vulgaris.
Descriptors		ACNE VULGARIS CLINDAMYCIN LIPOSOMES DRUG CARRIERS MICE DRUG DELIVERY SYSTEMS ELECTRON SPIN RESONANCE SPECTROSCOPY