Author/Editor		Ihan-Hren, Nataša; Gubina, Marija; Koželj, Vesna; Ihan, Alojz
Title		Immune response in chronic periapical parodontitis
Type		članek
Source		Pflugers Arch
Vol. and No.		Letnik 440, št. 5 Suppl
Publication year		2000
Volume		str. R86-8
Language		eng
Abstract		The purpose of our study was to investigate the immune response in chronical periapical parodontilis (CPP) by using multidisciplinary approach. 30 CPP samples were obtained after surgical removal - apicoectomy. Each CPP sample was examined by histological, bacteriological and flow cytometrical (FC) analysis of lymphocytes infiltrating CPP samples. Ten percent of bacteriological samples were sterile, others had significant aerobic and anaerobic growth We used pathohistologic and microbiologic findings and compare them to the results of imunological analysis. By FC we found a significant increase in proportions of T lymphocytes expressing interleukin-2 receptors and ICAM compared to peripheral blood lymphocytes. Proportions of T helper cells that produce interferon-gama (IFNgamma) was higher in CPP samples predominantly colonized by anaerobic bacteria There were no differences in IL-4 expression by T cells in both groups (anaerobic and streptoccoccal). Among anaerobic CPP samples differences in proportion of T cells that express IL-2 receptors expression was also found between samples colonised by Pacnes and Bacteroides sp. Oral streptococci cause relatively limited (issue destruction and induce Th2 type of immune response accompanied by non-cytotoxic inflammatory reaction. On the contrary, anaerobic bacteria induce. The type of immune response that cause more severe inflammatory reaction (type 4 of hypersensitivity that damage the tissue by the action of cytotoxic T cell activation.
Descriptors		PERIAPICAL PERIODONTITIS STREPTOCOCCUS T-LYMPHOCYTE SUBSETS APICOECTOMY BACTERIA, ANAEROBIC FLOW CYTOMETRY RECEPTORS, INTERLEUKIN INTERFERON TYPE II