Author/Editor | Frangež, Robert; Kosec, Marjan; Sedmak, Bojan; Beravs, Katarina; Demšar, Franci; Juntes, Polona; Pogačnik, Milan; Šuput, Dušan | |
Title | Subchronic liver injuries caused by microcystins | |
Type | članek | |
Source | Pflugers Arch | |
Vol. and No. | Letnik 440, št. 5 Suppl | |
Publication year | 2000 | |
Volume | str. R103-4 | |
Language | eng | |
Abstract | The subchronic effects of cyanobacterial lyophilizate (CL) containing microcystins on liver were investigated in female New Zeland rabbits. Sterilised CL containing microcystins was injected i.p. Liver toxicity was assessed by histological examination of liver samples. Noninvasive magnetic resonance imaging (MRI) of liver was also peformed in order to assess changes in the homogeneity of liver tissue. Subchronical intoxication with microcystins caused morphological changes of liver tissue that were also detected by use of MRI. Histological analysis showed that changes seen on MRI represent liver injury characterised with fatty infiltration and periportal fibrosis. This demonstrates that subchronic exposure to microcystins can lead to liver degeneration, which can easily be detected in vivo by use of MRI. | |
Descriptors | CYANOBACTERIA BACTERIAL TOXINS LIVER DISEASES RABBITS MAGNETIC RESONANCE IMAGING |