Author/Editor		Borovničar, Alenka; Keber, Irena; Stavljenić-Rukavina, Ana; Zaletel-Kragelj, Lijana
Title		Improvement of early functional atherosclerotic changes in males with hypercholesterolemia after vitamin E supplementation
Type		članek
Source		Pflugers Arch
Vol. and No.		Letnik 440, št. 5 Suppl
Publication year		2000
Volume		str. R126-8
Language		eng
Abstract		Vitamin E as an antioxidant vitamin reduces the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation and may have antiatherosclerotic effects. We tested the hypothesis that six months of 400 mg vitamin E supplementation favourably affects early functional changes in atherosclerotic process in subjects with hypercholesterolemia. The diameter of the brachial artery at rest, after reactive hyperemia (representing endothelium dependent vasodilatation) and after sublingual glyceryl trinitrate (representing endothelium - independent vasodilatation), were determined by ultrasonographic method (B mode) before and after the intervention period. After the intervention period the brachial endothelium - dependent vasodilatation increased significantly in the vitamin E group while it did not change in the placebo group. In conclusion, six months of oral vitamin E supplementation results in improvement of the endothelium-dependent vasodilatation in men with hypercholesterolemia.
Descriptors		ATHEROSCLEROSIS HYPERCHOLESTEROLEMIA VITAMIN E BRACHIAL ARTERY VASODILATION HYPEREMIA NITROGLYCERIN