Author/Editor		Martinuč, Jana; Drevenšek, Gorazd; Budihna, Metka V
Title		Action of mibefradil and lacidipine on the isolated human anterior tibial artery
Type		članek
Source		Pflugers Arch
Vol. and No.		Letnik 440, št. 5 Suppl
Publication year		2000
Volume		str. R147-8
Language		eng
Abstract		In isolated human anterior tibial artery the effects of two different types of calcium channel antagonists, mibefradil (a selective T-type Ca2+ channel antagonist) and lacidipine (a 1,4 dihydropyridine Ca2+ channel antagonist, acting at L- and T-type, but binds preferentially at L-type Ca2+ channels) were compared. Both drugs reduced the contradions of isolated arteries induced by 60 mM KCI. The potency (IC50) of mibefradil was 6.5 micro M and of lacidipine 82.4 nM. The potencies of both Ca2+ channel antagonists differed significantly (p<0.001 at 0.1 and 1 micro M; p<0.01 at 10 micro M). Lacidipine was 79-times more effective than mibefradil in reducing the vasoconstriction in isolated human anterior tibial artery. One of the reasons for higher potency of lacidipine couldd be a higher density of L-type than of T-type Ca2+ channels in tissue of the human anterior tibial artery.
Descriptors		TIBIAL ARTERIES CALCIUM CHANNEL BLOCKERS VASOCONSTRICTION POTASSIUM CHLORIDE