Author/Editor		Kožuh-Eržen, Nevenka; Kužner, Jernej; Drobnič-Košorok, Marinka
Title		The development of the method for the determination of terbinafine in cat's plasma and hair
Type		članek
Source		Pflugers Arch
Vol. and No.		Letnik 440, št. 5 Suppl
Publication year		2000
Volume		str. R168-70
Language		eng
Abstract		Clinical investigations of terbinafine indicate its high treatment activity against infections by several dermatophytes. Its efficiency was tested also in the treatment of microsporosis in cats. The distribution of terbinafine in cat's plasma and hair is important for the identification of the drug efficiency. A fast and reliable reversed-phase high performance liquid chromatographic method with appropriate sample preparation has been developed. Reliability, good reproducibility and low detection limit (LOD 0.25 ng/ml) of the method enable determination of terbinafine in hair and also in plasma of cats infected with Microsporum canis treated by Lamisil tablets.
Descriptors		DERMATOMYCOSES MICROSPORUM ANTIFUNGAL AGENTS HAIR CATS CHROMATOGRAPHY, HIGH PRESSURE LIQUID