Author/Editor     Vidan-Jeras, Blanka; Brinovec, Vlado; Jurca, Bojan; Levičnik-Stezinar, Snežna; Jeras, Matjaž; Bohinjec, Mateja
Title     The contribution of HLA-class II antigens in humoral non-response and delayed response to HBsAG vaccination
Type     članek
Source     Pflugers Arch
Vol. and No.     Letnik 440, št. 5 Suppl
Publication year     2000
Volume     str. R188-9
Language     eng
Abstract     The variability in the immune response modulated by HLA alleles may he an important factor for the induction of the protective effect of HBsAg vaccines. We present here the analysis of HLA-DRB1, DQB1 and DQA1 alleles and their combinations in the group of 36 individuals with poor humoral immmune response to HBsAg vaccination Comparison with the control group, consisted of 60 randomly choosen healthy subjects, revealed that the DRB1 * 1601, DQB1 *0502, DQA1 *O102 haplotype is overrepresented in the group of hyporesponders and may therefore be regarded as a factor influencing poor antibody responsiveness. We observed that after revaccination two of three individuals who failed to develop anti-HBs antibodies carry the same phenotype DRB1*0101,DRB1*0301;DQB1*0501, DQB1*0201;DQA1*0101,DQA1*0501, which supports the conjecture that immunogenicity of the HBsAg vaccine depends on specific combination of HLA DR and DQ molecules on antigen presenting cells.
Descriptors     HISTOCOMPATIBILITY ANTIGENS CLASS II
HEPATITIS B SURFACE ANTIGENS
HEPATITIS B VACCINES
HEPATITIS B ANTIBODIES
HAPLOTYPES
HLA-DR1 ANTIGEN
HLA-DQ ANTIGENS
POLYMERASE CHAIN REACTION