Author/Editor		Spencer, Kevin; Tul, Natasha; Nicolaides, Kypros H
Title		Maternal serum free beta-hCG and PAPP-A in fetal sex chromosome defects in the first trimester
Type		članek
Source		Prenat Diagn
Vol. and No.		Letnik 20
Publication year		2000
Volume		str. 390-4
Language		eng
Abstract		We have studied maternal serum free beta-hCG and PAPP-A, and fetal nuchal translucency (NT) in a series of 46 caves of fetal Turner's syndrome, 13 cases of other sex chromosomal anomalies end compared these with 947 control pregnancies in the first trimester. In cases of Turner's syndrome (45X) the median fetal NT was significantly higher than in controls (4 76 MoM), the median PAPP-A was significantly lower (0.49 MoM), whilst the free beta-hCG was not significantly different (1.1 MoM. For NT, 93% (43/46) of cases were equal to or greater than the 95th centile of controls for PAPP-A 35% (16/46) of cases were less than or equal to the 5th centile of controls and for free (beta-hCO 15% (7/46) of cases were equal to or greater than the 95th centile of controls- For other sex chromosomal anomalies (47XXX, XXY, XYY) the median NT was increased (2.07 MoM) whilst PAPP-A was not significantly decreased (0.88 MoM) and free beta-hCG was not significantly different (1.07 MoM) from controls. Using a previously derived multivariate risk algorithm for trisomy 21, incorporating NT, PAPP-A, free beta-hCG and maternal age, 96% of the Turner's cases and 62% of the other sex chromosomal anomalies would hove been identified.
Descriptors		CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN PRENATAL DIAGNOSIS SEX CHROMOSOME ABNORMALITIES PREGNANCY CROWN-RUMP LENGTH DOWN SYNDROME MATERNAL AGE NECK RISK FACTORS TURNER'S SYNDROME ULTRASONOGRAPHY, PRENATAL