Author/Editor		Maraspin-Čarman, Vera; Cimperman, Jože; Lotrič-Furlan, Stanka; Ružić-Sabljić, Eva; Strle, Franc
Title		Erythema migrans pri bolnikih, zdravljenih z imunosupresijo
Translated title		Erythema migrans in patients treated with immunosuppressive therapy
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 39, št. Suppl 4
Publication year		2000
Volume		str. 67-71
Language		slo
Abstract		In a prospective study performed at the Department of Infectious Diseases in Ljubljana from 1992-1999, 19 adult patients with typical erythema migrans (EM) and a previously identified immunocompromised condition as a consequence of immunosupressive therapy were investigated. The course and the outcome of borrelial infection were compared with 19 previously healthy, age, sex and antibiotic therapy-matched individuals for EM who were treated at our institution in the same year. Clinical and demographic characteristics of Lyme borreliosis before treatment with antibiotics and the duration of EM after the initiation of treatment were comparable in both groups. The occurrence of early disseminated borrelial infection before treatment and the frequency of treatment failure were found more often in immunocompromised patients than in the control group. Re-treatment was required more often by the immunocompromissed patients. In spite of the above mentioned defferences which were statistically nonsignificant, the outcome of borrelial infection after a one year follow-up period was favourable in both groups.
Summary		V prospektivno zastavljeni raziskavi, ki je potekala na Kliniki za infekcijske bolezni in vročinska stanja v Ljubljani v obdobju od 1992 do 1999, smo zajeli 19 odraslih bolnikov s tipičnim erythema migrans (EM), ki so bili imunsko kompromitirani zaradi prejemanja imunosupresivne terapije. Potek in izhod borelijske okužbe smo primerjali z 19 predhodno zdravimi bolniki z EM, ki so se ujemali po starosti, spolu in izboru antibiotičnega zdravljenja in so bili opazovani v istem obdobju. Osnovne klinične in demografske značilnosti lymske borelioze pred zdravljenjem z antibiotiki in trajanje EM po uvedbi antibiotičnega zdravljenja so bile primerljive v obeh skupinah bolnikov. Pojav zgodnje diseminirane oblike bolezni pred začetkom zdravljenja z antibiotiki in pogostost neuspeha zdravljenja smo našli pogosteje v skupini bolnikov z okrnjeno imunostjo. Ponovno zdravljenje je bilo v skupini bolnikov z okrnjeno imunostjo prav tako potrebno pogosteje kot v kontrolni skupini. Kljub navedenim razlikam, ki statistično niso bile pomembne, je bil izhod borelijske okužbe po enoletnem opazovalnem obdobju v obeh skupinah ugoden.
Descriptors		ERYTHEMA CHRONICUM MIGRANS IMMUNOCOMPROMISED HOST IMMUNOSUPPRESSIVE AGENTS LYME DISEASE