Author/Editor		Andoljšek, Dušan
Title		Nagnjenost h krvavitvam pri notranjih boleznih
Translated title		Bleeding tendency in internal diseases
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 39, št. Suppl 7
Publication year		2000
Volume		str. 17-21
Language		slo
Abstract		A mild congenital bleeding disorder not earlier recognised is seldom the cause of bleeding in patients with internal diseases. More often, these are the internal disease itself or its treatment. Coagulation disorders and thrombocytopenia in connection with enlarged spleen appear frequently in chronic hepatic diseases. Precise laboratory evalualuation of hemostatic disorder in these diseases is mandatory due to the diagnostic and prognostic value. Renal insufficiency is accompanied by the disturbances in primary hemostasis. The pathogenesis is mostly unknown. Autoimmune thrombocytopenia and lupus inhibitor are often found in inflammatory rheumatic diseases. There are several hemostatic disturbances in cancer patients. Cancer treatment with cytostatic drugs and X-ray can also be their cause. Disseminated intravascular coagulation can often be found in adenocarcinomas, autoimmune thrombocytopenia in lymphoproliferative diseases, and lupus inhibitor in dysproteinemias.
Summary		Nagnjenost h krvavitvam se pri notranjih boleznih pojavlja zaradi v otroštvu neprepoznane in blage prirojene motnje v hemostazi, zaradi notranje bolezni same ali zaradi zdravljenja. Pri kroničnih boleznih jeter gre za motnje v koagulaciji in trombocitopenijo, če je zvečana vranica. Lahko gre za krvavitve ali pa te nastanejo šele pri diagnostičnih in terapevtskih posegih. Podrobna laboratorijska opredelitev motnje v koagulaciji ima napovedni pomen za bolezen. Posledica motenj v delovanju ledvic so motnje primarne hemostaze. Patogeneza motenj je slabo poznana. Pri vnetnih revmatičnih boleznih je pogosta avtoimunska trombocitopenija, pa tudi pojav lupusnega zaviralca. Pri raku so motnje zelo različne in pogosto posledica zdravljenja s citostatiki in ionizirajočimi žarki. Diseminirana intravaskularna koagulacija je pogosta pri adenokarcinomih, avtoimunska trombocitopenija pri limfoproliferativnih boleznih, pojav beljakovin z lastnostjo inhibitorja pri paraproteinemijah.
Descriptors		INTERNAL MEDICINE HEMORRHAGE BLOOD COAGULATION DISORDERS LIVER DISEASES KIDNEY DISEASES RHEUMATIC DISEASES NEOPLASMS DISSEMINATED INTRAVASCULAR COAGULATION