Author/Editor		Ficko, Tanja
Title		Hemopoeza: proces nastajanja, diferenciacije in razvoja krvnih celic
Type		članek
Source		In: Musar A, Florjančič U, editors. Raziskovalno delo podiplomskih študentov Slovenije: naravoslovje in tehnika. 1. dnevi podiplomskih študentov Slovenije; 2000 nov 10; Ljubljana. Ljubljana: Društvo mladih raziskovalcev Slovenije,
Publication year		2000
Volume		str. 25-33
Language		slo
Abstract		The adult hematopoietic system is a complex series of multipotent and unipotent cell intermediates which proliferate and differentiate into at least eight morphologically and functionally different mature cell types. Hematopoietic hierarchy has been viewed as unidirectional process, involving gradually loss of self renewal ability, an increase tendency to reside in cell cycle activated state and ever large population of cells. The most primitive cells of hematopoiesis are pluripotent hematopoietic stem cells, with large self-renewal potential and proliferation ability. Hematopoietic stem cell undergoes early division into two types of committed progenitor cells: mieloid progenitor cells, which are the precursors of erythrocytes, platelets, neutrophils, basophils, eosinophils and mast cells, and lymphoid progenitor cells, which give rise to lymphocytes T and lymphocytes B. The process of hematopoiesis is regulated with a complex network of growth factors, receptors, cytokines, chemokines, transcription factors and some important genes. Scientist are now studying the effect of different combination of regulatory molecules on hematopoiesis and the ability to grow hematopoietic cells in vitro. These knowledge is important for bone marrow transplantation and treatment of hematopoetic diseases.
Descriptors		HEMATOPOIESIS HEMATOPOIETIC STEM CELLS ERYTHROPOIESIS GRANULOCYTES MACROPHAGES MEGAKARYOCYTES