Author/Editor		Reš-Muravec, Uršula
Title		Vpliv retiniranih testisov in orhidopeksije na plodno sposobnost moškega
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2000
Volume		str. 53
Language		slo
Abstract		Objective: Cryptorchidism is the most common developmental disorder in male children. In newborn the incidence is 2-4%. There is a natural descent in the scrotum in more than 50% of cases after the 1st year of life. For the undescended testes the treatment is essential. Orchidopexy of fixation of testes in the scrotum is the most common operation performed in childhood. Purpose: The aim of this study was to investigate the influence of unilateral and bilateral cryptorchidim with orchidopexy and age at orchidopexy on men fertility potential. The role of inhibin B was investigated as a new marker of spermatogenesis. The correlation between inhibin B and follicle-stimulating hormone (FSH), between both hormones and sperm concentration and between both hormones and age at operation was studied. Methods: There were 68 men (age 25-30 years) included in the study, 49 men after unilateral and 19 after bilateral orchidopexy. In the unilateral group there were 26 men operated before 8 and 23 men operated after 8 years of age. The fertility potential in men was estimated with semen analysis: sperm concentration, motility, morphology and testicular volume and hormonal status: FSH and inhibin B concentration. The differences in fertility potential were analyzed with the nonparametric Mann-Whitney test. Results: We found that fertility potential was statistically significantly decreased in the bilateral group compared to the unilateral group in sperm motility, in inhibin B concentration, testicular volumen and sperm concentration. The following parameters show that fertility potential was statistically significantly better when orchidopexy was performed before the age of 8: higher inhibin B concentration, larger testes, lower FSH concentration and higher sperm motility. There were no statistically significant differences in sperm morphology between the two groups. (Abstract truncated at 2000 characters).
Descriptors		CRYPTORCHIDISM SPERMATOGENESIS FERTILITY ADULT INHIBIN FSH SPERM COUNT SPERM MOTILITY TESTIS