Author/Editor		Pavelić, Jasminka; Lamovec, Janez; Novak, Janez; Gall-Trošelj, Koraljka; Kapitanović, Sanja; Pavelić, Krešimir
Title		Collision tumour in the pelvic cavity: rectal leiomysarcoma and prostate adenocarcinoma
Type		članek
Source		J Cancer Res Clin Oncol
Vol. and No.		Letnik 126, št. 2
Publication year		2000
Volume		str. 95-100
Language		eng
Abstract		We report a rare and, to our knowledge, as yet u derscribed type of collision tumour - rectal leiomyosarcoma and prostate adenocarcinoma. Our study also provides the first data on molecular alterations (polymerase chain reaction/loss of heterozygosity (LOH) analysis) of the APC, NF-1, DCC, p53, nm23-H1 and BRCA-1 genes in the two components of the collision tumour. None of the genes examined in this study expressed LOH in the prostate carcinoma component of the collision tumour. By contrast, in the leiomyosarcoma component, LOH was found at the DCC and p53 genes, proving that these two tumours did not arise from the same stem cell but represent two different neoplastic growths.
Descriptors		PROSTATIC NEOPLASMS ADENOCARCINOMA LIOMYSARCOMA RECTAL NEOPLASMS IMMUNOHISTOCHEMISTRY FLOW CYTOMETRY LOSS OF HETEROZYGOSITY MIDDLE AGE