Author/Editor		Čufer, T
Title		Adjuvant therapy of breast cancer: update
Type		članek
Source		Ann Oncol
Vol. and No.		Letnik 10, št. Suppl 6
Publication year		1999
Volume		str. S129-37
Language		eng
Abstract		The theoretical prediction that breast cancer is a systemic disease, and the patients may benefit from addition of a systemic therapy to local treatment, has now been confirmed by three decades of clinical investigations. A long-term follow up of individual trails and the International Overview based on meta-analysis clearly showed the potential of both hormonal therapies and chemotherapy to prolong disease-free and overall survival in nearly all groups of patients. The benefits have been demonstrated for both premenopausal and postmenopausal patients, with both node-negative and node-positive disease. However, there is still considerable uncertainty regarding the most appropriate treatment for each individual patient. In the present review, the results of meta-analysis are highlighted in the context of the new trials supporting the value of chemoendocrine therapy and anthracycline-based therapy. The results of prospective randomised trials evaluating the role of dose intensification, drug sequencing and dose density are discussed. Also presented are new treatment strategies, such as preoperative chemotherapy and highdose chemotherapy with stem cell support, the value of which remains to be confirmed. Future possibilities opened by inclusion of biologics into adjuvant therapy are discussed.
Descriptors		BREAST NEOPLASMS CHEMOTHERAPY, ADJUVANT TAMOXIFEN CYCLOPHOSPHAMIDE FLUOROURACIL METHOTREXATE ANTHRACYCLINES SURVIVAL ANALYSIS