Author/Editor		Golouh, Rastko; Zidar, Andreja
Title		Subungual osteogenic malignant melanoma: a case report
Type		članek
Source		Int J Surg Pathol
Vol. and No.		Letnik 4, št. 4
Publication year		1997
Volume		str. 249-54
Language		eng
Abstract		Osteogenic melanoma may mimic many other, especially osteogenic sarcoma; only 12 cases have been reported so far. To characterize this unusual neoplasm further, we present the clinicopathologic findings of a new case. A 67-year-old woman was treated unsuccessfully for "fungal granuloma" of her great toe. After nail ablation and incisiional biopsy, the toe was exarticulated. Histologically, we found a high-grade, spindle, focally epithelioid, amelanotic malignant tumor with a distinct osteoid and chondroid matrix. Spindle, epithelioid, osteoblastic, and chondroblastic tumor cells were immunoreactive for vimentin, S-100 protein, and NKI/C3. Ultrastructurally, diagnostic premelanosomes were not identified. Features that support a diagnosis of osteogenic melanoma are superficial subungual location, absence of bone involvement, and immunoreactivity for vimentin, S-100 protein, and NKI/C3. The unusual features of current tumor are absence of radial growth phase, negative reaction to HMB-45, and ultrastructural absence of melanosomes.
Descriptors		MELANOMA TOES OSTEOBLASTS IMMUNOHISTOCHEMISTRY MICROSCOPY, ELECTRON