Author/Editor     Dolinšek, Jernej
Title     Ugotavljanje celiakije pri ožjih družinskih članih bolnikov s celiakijo - diagnotična vrednost serumskih antigliadinskih in antiendomizijskih protiteles
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2000
Volume     str. 69
Language     slo
Abstract     The features of coeliac disease are changing. The prevalence of the disease is constantly increasing, and atypical and asymptomatic forms of the disease are being diagnosed more often. All untreated coeliac disease patients are at the risk of developing serious late complications of the disease. The need for early detection of all patients is therefore obvious and serological markers have proven to be the most powerful tool. Coeliac disease is known to be more common in certain groups. These groups are: patients with insulin dependent diabetes mellitus, patients with Down's syndrome, patients with autoimmune thyroid disorders, patients with Sjoegren's syndrome, cystic fibrosis, epilepsy and ataxia, patients with low stature, IgA deficit etc. Family members of known coeliac disease patients certainly represent one of the most important groups. Prevalence of the disease among family members is estimated to be between 1% and 12%. In order to assess the prevalence of the disease among family members of our patients we screened 106 first-degreee relatives of 45 coeliac disease patients. We analysed antigliadin (AGA) and antiendomysium (EMA) antibodies in all family members. Small bowel biopsy was recommended to relatives with positive serology. Biopsy speciemens were histologicaly examined. The prevalence of the disease was calculated as the number of coeliac disease patients among 100 first-degree relatives. Altogether 16 relatives (15.04%) had an increased level of at least one serological marker of coeliac disease. 15 relatives (14.15%) had an increased level of antigliadin antibodies IgG and 5 relatives (4.72%) had an increased level of antiendomysium antibodies. Only 4 relatives (3.77%) had increased levels of both antigliadin and antiendomysium antibiodies. (Abstract truncated at 2000 characters).
Descriptors     CELIAC DISEASE
FAMILY
IGG
IGA
AUTOANTIBODIES
INTESTINE, SMALL
BIOPSY
PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE