Author/Editor		Šega-Jazbec, Saša
Title		Klinične značilnosti in epidemiologija multiple skleroze
Type		članek
Source		In: Dšuban G, Šilc T, Vodušek DB, et al, editors. Simpozij Ocenjevanje invalidnosti, telesne okvare in potrebe po pomoči in postrežbi drugega pri nevroloških bolnikih; 2000 dec 8-9; Ljubljana. Ljubljana: Zavod za pokojninsko in invalidsko zavarovanje Slovenije, Invalidska komisija 2. stopnje,
Publication year		2000
Volume		str. 91-9
Language		slo
Abstract		Multiple sclerosis (MS) is one of the leading causes of neurologic disability in young adults. The disease has its onset between the ages of 20 and 40 in more than 50 % of patients. MS is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with early axonal involvement which is the main cause of disability. The course of MS may be classified as relapsing-remitting, secondary progressive and primary progressive. Because areas of focal demyelination are disseminated throughout the CNS the signs and symptoms of MS may be variable with weakness in one or more limbs, paresthesia, visual loss, diplopia, gait and balance disturbance beeing most often. Benign MS (a low disability after IS years of disease) occurs in less than 20 % of patients, atleast 50 % of patients will be using a cane and 30 % will require the wheelchair within 15 years of disease onset. Diagnosis of MS is based on finding the dissemination of white matter lesions in both space in time. The diagnosis of MS is still a clinical one. No pathognomonic diagnostic test for MS is available, but paraclinical tests in particular MRI, cerebrospinal fluid examination and evoked potentials play a role in confirrning the diagnosis.
Descriptors		MULTIPLE SCLEROSIS PROGNOSIS