Author/Editor		Reberšek, Martina; Čufer, Tanja; Rudolf, Zvonimir; Serša, Gregor
Title		Electrochemotherapy with cisplatin of breast cancer tumor modules in a male patient
Translated title		Elektrokemoterapija s cisplatinom pri bolniku z rakom dojke
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 34, št. 4
Publication year		2000
Volume		str. 357-61
Language		eng
Abstract		Background. The metastases of breast cancer in a male patient were treated with electrochemotherapy by intratumoral injection of cisplatin. Electrochemotherapy is chemotherapy with the subsequent local application of electric pulses to the tumor nodules in order to increase drug delivery into the cells. Case report. Cutaneous metastases of breast cancer were treated with the intratumoral administration of cisplatin and by 8 electric pulses (1300 V/cm) applied a minute later to each cutaneous metastasis. The treatment resulted in complete response of two electrochemotherapy treated cutaneous metastases and partial response of the third metastasis. In cutaneous metastases treated with intratumoral administartion of cisplatin without electric pulses, only partial response was obtained. Conclusion. This study confirms that electrochemotherapy with cisplatin is effective in the treatment of breast cancer metastases, too, as it was already proved for electrochemotherapy with bleomycin.
Summary		Izvleček. Avtorji so zdravili kožne metastaze pri bolniku z rakom dojke z elektrokemoterapijo s cisplatinom. Elektrokemoterapija je zdravljenje s kemoterapijo, ki ji sledi lokalna aplikacija električnih pulzov na tumorske lezije; električni pulzi povečajo vnos kemoterapevtika v celice. Prikaz primera. Avtorji so zdravili kožne metastaze raka dojke z intratumorsko aplikacijo cisplatina in 8 električnimi pulzi, ki so jih na vsako kožno metastazo aplicirali 1 minuto po vnosu cisplatina. Pri zdravljenju z elektrokemoterapijo so pri dveh kožnih metastazah dosegli popolni odgovor, pri 1 kožni metastazi pa delni odgovor. Pri kožnih metastazah, ki so jih zdravili samo z intratumorsko aplikacijo cispatina, pa so dosegli le delni odgovor. Zaključek. Elektrokemoterapija s cisplatinom je tako kot elektrokemoterapija z bleomicinom učinkovita pri zdravljenju kožnih metastaz raka na dojk.
Descriptors		BREAST NEOPLASMS, MALE CISPLATIN DRUG DELIVERY SYSTEMS ELECTROPORATION