Author/Editor     Božič, Mojca; Stegnar, Mojca; Fermo, Isabella; Ritonja, Anka; Peternel, Polona; Stare, Janez; D'Angelo, Armando
Title     Mild hyperhomocysteinemia and fibrinolytic factors in patients with history of venous thromboembolism
Type     članek
Source     Thromb Res
Vol. and No.     Letnik 100, št. 4
Publication year     2000
Volume     str. 271-8
Language     eng
Abstract     Mild hyperhomocysteinemia is recognized as a risk factor for venous thromboembolism (VTE), though its role in the thrombogenic processes is not understood. Its possible association with impaired fibriolysis was investigated in 157 patients (61 women, 96 men) below the age of 60 years (43+-11, mean +- SD) with a history of objectively confirmed TE. Patients had significantly higher fasting total plasma homocysteine (tHcy) levels than 138 apparently healthy subjects (8.0, 6.6-9.9 micromol/L vs. 7.2, .9-8.6 micromol/L, P=0.001; median, range between first and third quartile). In 17 of 157 patients (12%) yperhomocysteinemia (tHcy>11.4 wmol/L for women and tHcy>12.6 micromol/L for men) was established. The adjusted odds ratio as an estimate of relative risk for VTE was 2.3 (0.8-7.0; 95% confience interval). When patients with hyperhomocysteinemia were compared to patients without hyperhomocysteinemia, no significant differences in t-PA (antigen 9.2+-5.5 microg/L and 9.7+-4.7 microg/L, respectively; activity 1.3+-0.5 IU/mL and 1.3+-0.7 U/mL, respectively) and PAI-1 (antigen 19.3+- 7.5 microg/L and 22.6+-20.4 microg/L, respectively; activity 15.0+-12.6 and 15.8+-13.3 IU/mL, respectively) were observed. In conclusion, this study showed an association between mild hyperhomocysteinemia and VTE, but provided no evidence for an independent association between hyperhomocysteinemia and alterations in fibrinolytic proteins.
Descriptors     THROMBOPHLEBITIS
HOMOCYSTEINE
ALTEPLASE
PLASMINOGEN ACTIVATOR INHIBITOR 1
CHOLESTEROL
LIPOPROTEINS, LDL CHOLESTEROL
TRIGLYCERIDES
LIPOPROTEINS, HDL CHOLESTEROL
VITAMIN B 12
FOLIC ACID
ODDS RATIO