Author/Editor		Glavan, Gordana; Zorec, Robert; Babič, Ksenja; Sket, Dušan; Živin, Marko
Title		Dopaminergic regulation of synaptotagmin I and IV mRNAs in hemiparkinsonian rats
Type		članek
Source		Neuroreport
Vol. and No.		Letnik 11, št. 18
Publication year		2000
Volume		str. 4043-7
Language		eng
Abstract		Synaptotagmins (Syts) I and IV are synaptic proteins involved in the regulation of neurosecretion. Dopaminergic drugs have been shown to modulate their expression. Here we investigate whether dopaminergic regulation of syt I and syt IV expression could play a role in the hypersensitive striatum of rats with unilateral lesions of dopaminergic nigrostriatal neurons with 6hydroxydopamine. We show that chronic dopaminergic denervation resulted in a small down-regulation of striatal syt I mRNA whereas acute treatment with SKF-82958, a dopamine DI receptor agonist, induced a massive syt IV mRNA upregulation in the striatum on the lesioned side. We conclude that chronic lack of dopamine and treatment with dopamine depleted basal ganglia.
Descriptors		CORPUS STRIATUM NEUROSECRETION GENE EXPRESSION RNA, MESSENGER RECEPTORS, DOPAMINE D1 RATS, WISTAR HYDROXYDOPAMINES IN SITU HYBRIDIZATION HISTOCYTOCHEMISTRY DENSITOMETRY AUTORADIOGRAPHY