Author/Editor		Cardesa, Antonio; Nadal, Alfons; Jares, Pedro; Fernandez, Pedro L; Campo, Elias
Title		Advances in pathology of laryngeal cancer. Experience of the Barcelona group
Type		članek
Source		In: Gale N, Žargi M, editors. Epithelial tumours of the head and neck. Proceedings of the 31st memorial meeting for professor Janez Plečnik under the auspices of the European society of pathology; 2000 Dec 7-8; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Publication year		2000
Volume		str. 8-11
Language		eng
Abstract		According to our results, as well as others reported in the literature, a model for laryngeal carcinama transformation and progression is suggested. Loss of tumour suppressor function is implicated in the first steps of malignant transformation, although it does not confer additional advantages to invasive tumours. Activation of oncogenes seems to participate in later steps, maybe at the very border of malignancy development. Once the invasive phenotype is acquired, the collabaration between oncogene activation and proteolytic enzymes production (as well as many other elements) is needed for further tumour progression.
Descriptors		LARYNGEAL NEOPLASMS LARYNGECTOMY DNA RNA DNA METHYLATION POLYMERASE CHAIN REACTION HETEROZYGOTE PROTEIN P53 CYCLINS